Can I take Iron supplements and Prozac together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between iron supplements and Prozac (fluoxetine). However, both substances can occasionally cause stomach-related side effects like nausea or indigestion.
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Why this happens
Iron supplements and fluoxetine are processed by the body through different pathways. Iron is absorbed in the digestive tract, while fluoxetine is metabolised primarily by the liver. They do not interfere with each other's absorption or effectiveness.
What you should do
You can safely take these together. To minimise potential stomach upset, you may wish to take your iron supplement with food (unless your doctor has told you to take it on an empty stomach for better absorption) and take your Prozac at a different time of day. If you experience significant nausea or constipation, speak with your pharmacist.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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