Can I take Lansoprazole and Mirabegron together?

Why this happens

Lansoprazole is a proton pump inhibitor used to reduce stomach acid, while mirabegron is a beta-3 adrenergic agonist used for overactive bladder. They are processed by different pathways in the liver and do not interfere with how the other is absorbed or excreted.

What you should do

You can continue to take both medications as prescribed by your doctor. As with any medication, if you notice any new or unusual side effects, you should mention them to your healthcare provider.

Important precautions

Severe uncontrolled high blood pressure

Do not take mirabegron if your blood pressure is very high (180/110 mmHg or higher) as it can cause a dangerous further increase in blood pressure. Your doctor should check your blood pressure before and during treatment.

Severe diarrhoea

Lansoprazole can increase your risk of serious bowel infections. If you develop severe or persistent watery diarrhoea, or a fever, contact your doctor immediately and do not take anti-diarrhoeal medicine.

Lupus (SLE) or skin reactions

Contact your doctor if you develop a skin rash, especially in areas exposed to the sun, as lansoprazole can cause a rare but serious autoimmune skin reaction.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking lansoprazole. Alcohol increases the amount of acid your stomach produces, which can make your symptoms worse and counteract the effects of the medicine.

It is best to avoid or strictly limit alcohol while taking mirabegron. Alcohol can worsen the symptoms mirabegron is treating, such as urinary urgency and frequency, and may increase the risk of side effects like dizziness.

Food (Timing)

Lansoprazole works best if you take it at least 30 minutes before food. Taking it with or after food can make it less effective at reducing stomach acid.

Caffeine

You should limit your intake of caffeine (found in coffee, tea, and energy drinks). Caffeine is a bladder irritant and a diuretic, which can worsen the overactive bladder symptoms that mirabegron is intended to treat.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.