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Can I take Lanzoprole and Naproxen together?

Drug interaction guide

Lansoprazole is actually often prescribed alongside naproxen to protect your stomach. Naproxen can irritate the stomach lining and cause ulcers, while lansoprazole reduces stomach acid to prevent this damage. However, lansoprazole can slightly change how quickly or how much naproxen is absorbed into your bloodstream.

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Why this happens

Lansoprazole increases the pH (reduces the acidity) of the stomach. Because naproxen needs a certain level of acidity to dissolve and be absorbed efficiently, the presence of lansoprazole can slightly alter its absorption profile. This is generally considered a 'beneficial' interaction because the protective effect on the stomach outweighs the minor change in drug absorption.

What you should do

It is safe and common to take these together. In fact, if you are taking naproxen long-term, your doctor likely prescribed lansoprazole specifically to prevent stomach ulcers. Take them exactly as directed by your healthcare professional. If you notice any unusual stomach pain or black, tarry stools, contact your doctor immediately.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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