Can I take Lion's mane and Red vine leaf extract together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Both lion's mane and red vine leaf extract have properties that can slow down blood clotting. Taking them together might increase the risk of bruising or bleeding, although the risk is generally low for healthy individuals.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Lion's mane contains compounds that may inhibit platelet aggregation (the 'stickiness' of blood cells). Red vine leaf extract contains flavonoids that improve blood flow and may also have mild anti-clotting effects. Combining them creates an additive effect on blood thinning.
What you should do
Back to contentsIt is generally safe to take these together in standard doses, but you should monitor for any unusual bruising, nosebleeds, or bleeding gums. If you are scheduled for surgery, stop taking both supplements at least two weeks beforehand. If you are already taking prescribed blood thinners (like warfarin or aspirin), consult your doctor before combining these supplements.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take 4.5mg and Metformin together?
There is no known direct interaction between low-dose naltrexone (4.5mg) and metformin. However, both medications can sometimes cause similar stomach-related side effects, such as nausea or diarrhoea, which might be more noticeable if you start them at the same time.

Drug interactions checker
Can I take 50 and Vitamin d3 together?
There is no known interaction between 50 (assuming this refers to 50mg of a standard supplement or a common medication) and Vitamin D3. However, if '50' refers to a specific medication not named, please provide the full name. Vitamin D3 is generally very safe and does not interfere with most common medications.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.