Can I take Lions mane and Shilijet together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There are no known direct drug-drug interactions between Lion's Mane mushroom and Shilajit. However, both substances may have a mild effect on lowering blood sugar and thinning the blood. Taking them together could theoretically increase these effects, though this is not well-documented in clinical studies.
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Why this happens
Lion's Mane (Hericium erinaceus) and Shilajit both contain bioactive compounds that may improve insulin sensitivity and possess mild antiplatelet (blood-thinning) properties. When combined, they may have an additive effect on these systems.
What you should do
Back to contentsIt is generally considered safe to take these together for most healthy individuals. However, if you have diabetes or are taking blood-thinning medication (like warfarin or aspirin), you should monitor your blood sugar levels closely and watch for any unusual bruising or bleeding. Always consult your GP before starting new supplements, especially if you have an upcoming surgery.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
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Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
Treatment and medication
Can I take 7.5mg and Medikinet together?
Taking Zopiclone and Medikinet (methylphenidate) together can cause a 'tug-of-war' effect in your body. Medikinet is a stimulant designed to wake you up and help you focus, while Zopiclone is a sedative designed to make you sleepy. Taking them at the same time can make both medicines less effective. Additionally, while Medikinet is active, it may be harder for you to fall asleep, even after taking Zopiclone. In some cases, mixing stimulants and sedatives can lead to unpredictable effects on your coordination, heart rate, or mental state (such as feeling confused or agitated).
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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