Can I take Magnesium 5 in one and Progynova together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking magnesium supplements at the same time as Progynova (estradiol) may slightly reduce how much of the hormone your body absorbs. This could potentially make your hormone replacement therapy (HRT) less effective.
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Why this happens
Magnesium can bind to certain medications in the digestive tract or change the acidity of the stomach, which can interfere with how well the body absorbs oestrogen.
What you should do
You do not need to stop taking either, but it is best to separate the doses. Take your Progynova at least 2 hours before or 4 to 6 hours after taking your magnesium supplement. If you notice a return of menopause symptoms (like hot flushes), speak to your doctor.
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Important precautions
Blood clots and stroke
This medicine significantly increases your risk of developing blood clots (DVT or pulmonary embolism) and stroke. Seek immediate medical help if you experience painful leg swelling, sudden chest pain, or breathlessness.
Severe kidney impairment
If you have severe kidney disease, you must not take magnesium supplements. Your kidneys may not be able to remove excess magnesium from your blood, which can lead to dangerous levels affecting your heart and breathing.
Breast cancer
Progynova can stimulate the growth of certain types of breast cancer. You must perform regular breast self-checks and attend all scheduled mammograms while using this treatment.
Food and drink warnings
Grapefruit juice
Grapefruit juice can increase the levels of estradiol in your blood, which may increase the risk of side effects. It is best to avoid large amounts of grapefruit juice while taking this medicine.
Dairy products (Milk, Cheese, Yoghurt)
Calcium-rich foods like dairy can interfere with how your body absorbs magnesium if taken at the same time. Try to space out your magnesium supplement and dairy intake by at least 2 hours.
Alcohol
Regular or excessive alcohol consumption can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective.
Caffeine (Coffee, Tea, Energy drinks)
High intake of caffeine can have a mild diuretic effect, which may increase the excretion of magnesium from the body.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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