Can I take Magnesium and Vitamin C together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no harmful interaction between magnesium and vitamin C. In fact, taking them together is generally considered safe and may even be slightly beneficial for absorption.
Why this happens
Vitamin C creates a more acidic environment in the stomach, which can help the body dissolve and absorb certain forms of magnesium more effectively. They do not interfere with each other's metabolism or excretion.
What you should do
You can safely take these two supplements together. However, be aware that high doses of either magnesium or vitamin C can cause diarrhoea or stomach upset. If you experience these symptoms, try taking them at different times of the day or reducing the dose.
Important precautions
Kidney disease
If you have severe kidney problems, your body may not be able to remove excess magnesium, leading to dangerously high levels in the blood. Check with your doctor before use.
Kidney stones (renal calculi)
High doses of vitamin C can increase the amount of oxalate in your urine, which significantly raises the risk of developing kidney stones, especially if you have had them before.
G6PD deficiency
Very high doses of vitamin C can cause oxidative stress and lead to the breakdown of red blood cells (haemolysis) in individuals with G6PD deficiency.
Haemochromatosis
High doses of vitamin C can significantly increase the amount of iron your body absorbs from food. If you have haemochromatosis, this can lead to dangerous levels of iron buildup, which may damage your heart and liver. Avoid vitamin C supplements unless specifically directed by your specialist.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking magnesium. Alcohol acts as a diuretic, which can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective. Additionally, chronic alcohol use can lead to magnesium deficiency.
Dairy products (Milk, Cheese, Yoghurt)
Avoid taking magnesium supplements at the same time as large amounts of dairy products. Dairy is high in calcium, and high doses of calcium can compete with magnesium for absorption in the gut, meaning you may not get the full benefit of your supplement. It is best to space them at least 2 hours apart.
Caffeine (Coffee, Tea, Energy drinks)
It is best to limit caffeine intake around the time you take magnesium. Like alcohol, caffeine has a mild diuretic effect and can increase the excretion of magnesium through the kidneys.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Allopurinol and Nortriptyline together?
There is no known direct interaction between allopurinol and nortriptyline. However, both medications can occasionally cause side effects that affect the liver or blood counts. Taking them together does not typically increase these risks, but it is important to be aware of how you feel.

Drug interactions checker
Can I take Mounjaro and Insulin together?
Taking Mounjaro (tirzepatide) and insulin together significantly increases your risk of having a 'hypo' (hypoglycaemia), which is when your blood sugar levels drop too low. Symptoms of a hypo can include feeling shaky, sweaty, dizzy, hungry, or confused. In severe cases, it can be dangerous.
Article history
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
Join the conversation
Share your thoughts or experiences with others in our patient communities.

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amitriptyline and Oxycodone together?
- Can I take Amlodipine and Nustendi together?
- Can I take Ashwagandha and Vitamin B2 together?
- Can I take Aspirin and Methotrexate together?
- Can I take Atorvastatin and Rybelsus (semaglutide) together?
- Can I take Benylin dry coughs and Clozapine together?
- Can I take Colecalciferol and Ezetimibe together?
- Can I take Danazol and Lansoprazole together?
- Can I take Ibuprofen and Quinine together?
- Can I take Ibuprofen gel 10% and Lactulose together?
- Can I take Lactulose and Quinine together?
- Can I take Levothyroxine and Losartan together?
- Can I take Losartan and Rybelsus together?
- Can I take Magnesium and St John's wort together?
- Can I take Mirtazapine and Nortriptyline together?
- Can I take Oestrogel pump-pack and Vitamin C together?
- Can I take Paracetamol and Gabapentin together?
- Can I take Solifenacin and Vitamin C together?
- Can I take Venlafaxine and Vitamin B12 together?
- Can I take Warfarin and Amoxicillin together?