Can I take Moringa leagg and Progynova together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Moringa may reduce the effectiveness of Progynova (estradiol). This could lead to your hormone replacement therapy or contraception not working as well as it should. Additionally, both substances are processed by the liver, which could theoretically affect how much of the medication stays in your bloodstream.
In this article:
Continue reading below
Why this happens
Moringa oleifera is thought to have 'antioestrogenic' properties, meaning it may block or interfere with the way oestrogen works in the body. It may also speed up the liver enzymes (specifically CYP3A4) that break down Progynova, causing the medicine to leave your body too quickly.
What you should do
You should consult your doctor before taking Moringa alongside Progynova. If you decide to use both, monitor for signs that your medication isn't working, such as a return of menopause symptoms or breakthrough bleeding.
Continue reading below
Important precautions
Blood clots and stroke
This medicine significantly increases your risk of developing blood clots in the legs (DVT) or lungs (PE). Seek immediate medical help if you experience painful leg swelling, sudden chest pain, or breathlessness.
Breast and endometrial cancer
Long-term use can increase the risk of breast cancer and thickening of the womb lining. You must report any unexplained vaginal bleeding to your doctor immediately.
Food and drink warnings
Grapefruit juice
Grapefruit juice can increase the levels of estradiol in your blood, which may increase the risk of side effects such as breast tenderness, nausea, or headaches. It is best to avoid large amounts of grapefruit juice while taking this medicine.
Alcohol
Drinking alcohol while taking oestrogen replacement therapy can lead to higher levels of estradiol in your blood than intended. This may increase the risk of side effects. It is advisable to keep your alcohol intake within recommended limits.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Atorvastatin and Sertraline together?
Taking atorvastatin and sertraline together may slightly increase the levels of atorvastatin in your blood. This can increase the risk of side effects, particularly muscle pain or weakness.
Treatment and medication
Can I take Idapamide and Ramipril together?
Taking indapamide and ramipril together can cause your blood pressure to drop too low, especially when you first start the combination. This can make you feel dizzy, lightheaded, or faint. It can also put extra strain on your kidneys.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.