Can I take Losartan and Trazodone together?

Why this happens

Both losartan and trazodone have the effect of lowering blood pressure. Losartan is specifically designed to do this, while trazodone (an antidepressant) can cause low blood pressure as a side effect. When used together, their effects add up.

You should monitor your blood pressure regularly at home. Be careful when getting out of bed or standing up; move slowly to give your body time to adjust. If you feel very dizzy, sit or lie down immediately. Inform your doctor if you experience frequent dizziness or fainting, as they may need to adjust your dosages.

Depression and mental health disorders

Trazodone can increase thoughts of self-harm or suicide, particularly when first starting the medicine or changing the dose. Monitor your mood closely and seek urgent medical help if you experience any distressing thoughts.

Serotonin Syndrome

When taken with other medicines that affect serotonin, trazodone can cause a life-threatening condition called serotonin syndrome. Seek immediate medical attention if you experience high fever, agitation, shivering, or muscle twitching.

Priapism (prolonged erection)

Trazodone can cause a painful, persistent erection that lasts for several hours. This is a medical emergency; if this occurs, stop taking the medicine and go to an A&E department immediately to avoid permanent damage.

Pregnancy

You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. Alcohol can increase the blood-pressure-lowering effect of losartan, making you feel dizzy or lightheaded. When combined with trazodone, alcohol will significantly increase drowsiness and may impair your coordination and judgement.

Potassium-rich foods (e.g., bananas, spinach, salt substitutes)

Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.

Grapefruit juice

Grapefruit juice may increase the amount of trazodone in your blood, which can increase the risk of side effects. It is best to avoid drinking large amounts of grapefruit juice while taking this medication.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.