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Can I take Omeprazol and Paracetamol together?

Drug interaction guide

There is no significant interaction between omeprazole and paracetamol. It is generally safe to take these two medicines together.

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Why this happens

Omeprazole reduces stomach acid, while paracetamol is mainly absorbed in the small intestine. While omeprazole can slightly change how quickly the stomach empties, studies show this does not have a meaningful effect on how well paracetamol works or its safety levels in the body. They are processed by different enzymes in the liver.

What you should do

You can take these medicines together as prescribed or according to the packaging instructions. You do not need to space them apart. If you find that your pain is not being controlled or if you develop new symptoms, speak with your pharmacist or GP.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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