Can I take Omeprazole and Setlers antacid spearmint flavour together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking Setlers antacid at the same time as omeprazole can make the omeprazole less effective. This is because the antacid can interfere with how the omeprazole tablet or capsule dissolves and is absorbed into your bloodstream.
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Why this happens
Omeprazole is often designed with a special coating to prevent it from breaking down in the stomach's acid. Setlers (calcium carbonate) neutralises stomach acid, which can cause the omeprazole to release too early or not be absorbed properly.
What you should do
You should space these medicines out. Take your omeprazole first (usually in the morning), and wait at least 2 hours before taking a Setlers antacid tablet.
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Important precautions
Severe diarrhoea
Contact your doctor immediately if you develop severe or persistent watery diarrhoea, as omeprazole can increase the risk of a serious bowel infection called C. difficile.
Masking serious symptoms
These medicines can hide the symptoms of more serious conditions. You must see a doctor if you have unexplained weight loss, persistent vomiting, or difficulty swallowing.
Drug interactions
Do not take these two medicines at the same time. Antacids can stop omeprazole from being absorbed properly; leave a gap of at least 2 hours between them.
Food and drink warnings
Alcohol
While alcohol does not directly interact with these medicines, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms you are trying to treat. It is best to limit alcohol intake if you have indigestion or acid reflux.
Caffeine (Coffee, Tea, Cola)
Caffeine can trigger or worsen symptoms of acid reflux and indigestion by relaxing the muscle at the bottom of the food pipe. This may make your medication feel less effective.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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