Can I take Omeprazole and Spironolactone together?

Why this happens

Both medications can independently influence how the body handles electrolytes. Spironolactone is a 'potassium-sparing' diuretic that prevents the body from flushing out potassium. Omeprazole can sometimes affect magnesium and potassium levels through its effect on the kidneys and stomach acid. When used together, there is a small additive risk of potassium levels rising too high.

What you should do

You can usually take these two medicines together, but you should have your blood monitored regularly by your doctor to check your kidney function and potassium levels. If you experience symptoms like muscle weakness, an irregular heartbeat, or tingling sensations, contact your doctor. Avoid using salt substitutes that contain potassium (often labelled as 'low sodium' salt) unless your doctor tells you otherwise.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.