Can I take Paracetamol and Statins together?

Why this happens

Paracetamol and statins are processed by the liver using different pathways. Paracetamol does not interfere with how statins work to lower cholesterol, nor do statins change how paracetamol relieves pain or fever.

What you should do

You can safely take paracetamol while on statin medication. Always follow the dosage instructions on the packet and do not exceed 4000mg (eight 500mg tablets) of paracetamol in a 24-hour period. If you have pre-existing liver problems, consult your doctor before taking these medicines together.

Important precautions

Liver health and multiple medicine use

Never take more than one medicine containing paracetamol at the same time. Exceeding the maximum dose can cause fatal liver failure, often with no immediate symptoms. Check labels of cold and flu remedies carefully.

Unexplained muscle pain

You must report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to a serious condition called rhabdomyolysis, which causes kidney damage.

Dietary interaction (Grapefruit)

Avoid drinking large amounts of grapefruit juice or eating grapefruit. It can significantly increase the level of the medicine in your blood, making serious side effects much more likely.

Food and drink warnings

Alcohol

While an occasional drink is generally safe, chronic heavy drinking or binge drinking increases the risk of severe liver damage when taking paracetamol. This is because both substances are processed by the liver.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.