Can I take Quetiamine and Sertraline together?

Why this happens

Both drugs can affect the electrical activity of the heart (the QT interval). When combined, this effect can be additive. Furthermore, both drugs influence serotonin levels; sertraline increases serotonin, and quetiapine can also affect serotonin receptors, potentially leading to an over-accumulation. Both drugs also have sedative properties that add together.

What you should do

You should speak to your doctor before taking these together. They may want to perform a simple heart trace (ECG) to check your heart rhythm. Seek medical help immediately if you feel dizzy, faint, or experience a fast or pounding heartbeat. Also, watch out for signs of serotonin syndrome, such as shivering, sweating, confusion, or muscle stiffness. Avoid driving or using heavy machinery until you know how this combination affects your alertness.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.