Antazoline and xylometazoline eye drops
Otrivine-Antistin
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 6 May 2024
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Otrivine-Antistin® drops relieve eye itching and redness associated with allergies.
Use one drop two or three times a day in both eyes. Do not use the drops for more than seven days.
When first put in, eye drops can cause blurred vision. Wait until this clears before you drive.
At a glance
Antazoline and xylometazoline eye drops treat red, watery, itchy eyes from allergies.
They work by reducing histamine effects and narrowing blood vessels in the eye.
Do not use for longer than 7 days without medical advice.
Get medical advice if your symptoms worsen or do not improve within a few days.
Do not wear soft contact lenses while using these drops unless advised otherwise.
In this article:
Video picks for Allergy medicines
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Overview
Type of medicine | Anti-allergy eye drops |
Used for | To relieve the eye symptoms of allergies such as hay fever |
Also called | Otrivine-Antistin® |
Available as | Eye drops |
What are antazoline and xylometazoline eye drops used for?
Back to contentsAntazoline and xylometazoline eye drops (brand name Otrivine-Antistin®) are used to treat allergic conjunctivitis.
Allergic conjunctivitis causes red, watery and itchy eyes. It is caused by exposure to irritants such as plant pollens, pet fur, cosmetics or house dust mite.
Antazoline and xylometazoline eye drops are available on prescription, or you can buy them without a prescription at a pharmacy. They can be used by adults and by children over 12 years of age.
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How do antazoline and xylometazoline eye drops work?
Back to contentsAntazoline and xylometazoline eye drops contain two active ingredients that work together to relieve eye symptoms caused by allergies such as hay fever.
Antazoline is an antihistamine that blocks the effects of histamine, a chemical released by the body during an allergic reaction. This helps reduce itching, watering, and irritation of the eyes.
Xylometazoline is a decongestant that narrows the blood vessels in the eye. This helps reduce redness and swelling.
Side effects of antazoline and xylometazoline eye drops
Back to contentsThe most common side effects of antazoline and xylometazoline eye drops are:
Burning.
Stinging.
You will find a full list in the manufacturer's information leaflet supplied with your drops.
Unwanted effects often improve as your body adjusts to a new medicine, but speak with your doctor or pharmacist if the following continues or becomes troublesome.
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How to manage side effects
Back to contentsAntazoline and xylometazoline eye drop side effects | What can I do if I experience this? |
Mild eye discomfort (such as burning or stinging) | This usually disappears within a few minutes of using the drops. Do not drive and do not use tools or machines unless your vision is clear |
Occasionally people can be allergic to eye drops, particularly when the eye drops contain a preservative.
If you notice a rash around your eyes, or any swelling or increased itching, stop using the drops and contact a doctor for advice.
If you experience any other symptoms which you think may be due to the eye drops, speak with your doctor or pharmacist for further advice.
Who should not use antazoline and xylometazoline eye drops?
Back to contentsTo make sure this is the right treatment for you, before you start using the eye drops it is important that your doctor or pharmacist knows:
If you wear soft contact lenses.
If you have any of the following: high blood pressure, an overactive thyroid gland, diabetes, increased pressure in your eye (glaucoma), heart or blood vessel disease, difficulty peeing or a tumour on your adrenal glands, called phaeochromocytoma.
If you are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only use medicines on the recommendation of a doctor.
If you have ever had an allergic reaction to an antihistamine or to any eye drops.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
How to use antazoline and xylometazoline eye drops
Back to contentsWash your hands well before you use the drops.
Remove the cap.
Tilt your head back a little and pull the lower lid of your eye out to form a pocket.
Hold the bottle upside down near to your eye. Try not to touch your eye as you do this.
Gently squeeze the bottle to release one drop into your eye. Only use a second drop if the first drop missed going into your eye.
Close your eye for a minute or two, and press gently on the side of your nose where the corner of your eye meets your nose. This helps to stop the drop from draining away and keeps it in your eye.
Repeat the process in your other eye.
Replace the cap.
Getting the most from your treatment
Back to contentsRead the leaflet before use. It explains how to use the drops and lists possible side effects.
Use the drops 2-3 times a day. Apply them to both eyes unless your doctor tells you otherwise.
Keep the dropper tip clean. Do not touch your eye, fingers, or any surface with the bottle tip.
Expect brief blurred vision. Wait until your vision is clear before driving or using tools or machinery.
Leave 5-10 minutes between different eye drops. This helps each medicine work properly.
Avoid soft contact lenses. Do not wear them while using the drops unless your doctor advises otherwise.
See a doctor if symptoms do not improve. Get medical advice if your symptoms worsen or have not improved within a few days.
Do not use for longer than 7 days. Most people notice an improvement within a few days, but treatment may be needed for up to a week.
How to store antazoline and xylometazoline eye drops
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Eye drops only keep for four weeks once the bottle has been opened so throw away the bottle after you have finished the course of treatment, even if there is some solution left.
Never keep opened bottles of eye drops to use later. This helps to prevent the risk of eye infections.
Frequently asked questions
Back to contentsHow quickly do antazoline and xylometazoline eye drops work?
The drops usually start to relieve eye allergy symptoms within a few minutes. Redness, itching, and irritation often improve shortly after use.
Can I use antazoline and xylometazoline eye drops every day?
Use the drops exactly as directed by your doctor, pharmacist, or the instructions in the pack. They are intended for short-term relief and should not be used for longer than recommended.
Can I use antazoline and xylometazoline eye drops with other eye drops?
Yes, but leave at least 5-10 minutes between different eye drops. This helps ensure each medicine is absorbed properly.
Can I wear contact lenses while using these eye drops?
Do not wear contact lenses while your eyes are red or irritated. If you wear lenses, follow the instructions in the patient leaflet and wait until your symptoms have improved before wearing them again.
Important information about all medicines
Back to contentsImportant information about all medicines
If you buy any medicines check with a pharmacist that they are safe to use with your other medicines.
Never use more than the recommended dose.
If you suspect that someone has swallowed some of this medicine by accident, contact the accident and emergency department of your local hospital for advice.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are using.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
MHRA - Reporting adverse reactions
Report suspected side effects to medicines, vaccines, e-cigarettes, medical device incidents, defective or falsified (fake) products to the Medicines and Healthcare products Regulatory Agency to ensure safe and effective use.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
How quickly do antazoline and xylometazoline eye drops work?
The drops usually start to relieve eye allergy symptoms within a few minutes. Redness, itching, and irritation often improve shortly after use.
Can I use antazoline and xylometazoline eye drops every day?
Use the drops exactly as directed by your doctor, pharmacist, or the instructions in the pack. They are intended for short-term relief and should not be used for longer than recommended.
Can I use antazoline and xylometazoline eye drops with other eye drops?
Yes, but leave at least 5-10 minutes between different eye drops. This helps ensure each medicine is absorbed properly.
Can I wear contact lenses while using these eye drops?
Do not wear contact lenses while your eyes are red or irritated. If you wear lenses, follow the instructions in the patient leaflet and wait until your symptoms have improved before wearing them again.
What should I do if my eye allergy symptoms don't improve after using these drops?
If your symptoms worsen or have not improved within a few days of using the eye drops, you should seek medical advice from a doctor.
What should I do if I accidentally get the eye drops in my mouth or swallow them?
If you suspect that someone has swallowed some of this medicine by accident, contact the accident and emergency department of your local hospital for advice.
What is the shelf life of these eye drops once opened?
Eye drops only keep for four weeks once the bottle has been opened. You should throw away the bottle after you have finished the course of treatment, even if there is some solution left, and never keep opened bottles to use later to prevent the risk of eye infections.
Further reading and references
- Manufacturer's PIL, Otrivine-Antistin® Eye Drops; Thea Pharmaceuticals Ltd, The electronic Medicines Compendium. Dated December 2021.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 31 Mar 2027
6 May 2024 | Latest version

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