Desloratadine
Neoclarityn
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 19 Jun 2023
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Desloratadine is called a non-drowsy antihistamine; however, it can still cause drowsiness in a few people.
Make sure your reactions are normal before you drive and before you use tools or machines.
Take one dose a day.
The most common side effect of desloratadine is tiredness (fatigue).
At a glance
Desloratadine is a non-drowsy antihistamine that treats symptoms of hay fever and hives.
It works by blocking histamine that the body releases during an allergic reaction.
Common side effects include feeling tired, dry mouth, and headache.
You can take desloratadine with or without food, once a day.
Tell your doctor if you are pregnant, have kidney problems, or have epilepsy.
Desloratadine usually starts working within 1 hour and lasts about 24 hours.
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Overview
Type of medicine | A non-drowsy antihistamine |
Used for | Hay fever (allergic rhinitis); hives (urticaria) |
Also called | Neoclarityn® |
Available as | Tablets and oral liquid medicine |
What is desloratadine used for?
Back to contentsDesloratadine is a non-drowsy antihistamine used to relieve symptoms caused by allergies.
It is commonly used to treat hay fever (allergic rhinitis), which can cause sneezing, a runny or blocked nose, and itchy or watery eyes.
It is also used to treat hives (urticaria), helping to reduce itching and skin rashes.
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How does desloratadine work?
Back to contentsDesloratadine works by blocking the effects of histamine that is released by the body after exposure to allergens such as pollen, animal fur or house dust mites.
Histamine is responsible for many allergy symptoms, including sneezing, a runny or blocked nose, and itchy or watery eyes.
By preventing histamine from binding to its receptors, desloratadine helps reduce these symptoms and provides relief from allergic conditions such as hay fever and hives.
Side effects of desloratadine
Back to contentsCommon side effects of desloratadine are:
Feeling tired or sleepy.
Dry mouth.
Headache.
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
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How to manage desloratadine side effects
Back to contentsThe unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Desloratadine side effects (these affect fewer than 1 in 10 people) | What can I do if I experience this? |
Feeling tired or sleepy | If this happens, do not drive and do not use tools or machines. Do not drink alcohol |
Dry mouth | Try chewing sugar-free gum or sucking sugar-free sweets |
Headache | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know |
If you experience any other symptoms that you think may be due to the medicine, speak with your doctor or pharmacist.
Who should not take desloratadine?
Back to contentsDesloratadine may not be suitable for everyone. It is important that your doctor knows:
If you are pregnant, trying for a baby, or breastfeeding.
If you have problems with the way your kidneys work.
If you have epilepsy or there is a family history of fits (seizures).
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to another antihistamine, or to any other medicine.
How to take desloratadine
Back to contentsRead the manufacturer's printed information leaflet from inside your pack. It will give you more information about desloratadine and a full list of side-effects which you may experience from taking it.
Recommended doses of desloratadine are:
For adults and for children aged over 12 years: 5 mg taken once a day.
For children aged 6-12 years: 2.5 mg taken once a day. This is 5 ml of the liquid medicine.
For children aged 1-6 years: 1.25 mg taken once a day. This is 2.5 ml of the liquid medicine.
If you are giving desloratadine liquid medicine to a child, make sure you follow the dosing instructions on the bottle carefully so that you measure out the correct dose.
You can take desloratadine before or after meals. Some people find it helps to swallow the tablets with a drink of water.
If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.
Getting the most from your treatment
Back to contentsMost people only need to take an antihistamine for a short while when they have symptoms. You should stop taking desloratadine once your symptoms have eased.
Although desloratadine is classed as a non-drowsy antihistamine, it can still cause drowsiness in a few people. If this happens to you, do not drive and do not use tools or machines.
If you drink alcohol while you are on desloratadine, be aware of its effects on you and do not drink more than moderate amounts. Alcohol can increase the risk of side-effects from antihistamines.
If you are having an operation, or any treatment or tests (particularly if it is to test for an allergy), make sure you say that you are taking an antihistamine.
If you buy any medicines, check with a pharmacist that they are suitable to take with an antihistamine. This is because a number of other medicines can increase the risk of side-effects.
How to store desloratadine
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Frequently asked questions
Back to contentsHow long does desloratadine take to work?
Desloratadine usually starts to work within about 1 hour, with full relief from allergy symptoms often building over the first few hours after taking a dose.
How long does desloratadine last?
A single dose of desloratadine works for around 24 hours. This is why it is taken once a day to provide all-day relief from allergy symptoms.
Can I take desloratadine every day?
Yes, desloratadine can be taken daily during allergy season or while symptoms persist. For long-term or continuous symptoms, your doctor may advise ongoing use, but it should be reviewed if symptoms continue for a long time.
What should I do if desloratadine does not work?
If your symptoms do not improve after a few days, speak to a pharmacist or doctor. You may need a different antihistamine or additional treatment to better control your allergy symptoms.
Can I take desloratadine when pregnant?
It is generally considered safe to use desloratadine during pregnancy. However, always let your doctor know if you are pregnant before taking it.
Important information about all medicines
Back to contentsImportant information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Further reading and references
- Manufacturer's PIL, Neoclarityn® 5 mg film-coated tablets; Organon Pharma (UK) Limited, The electronic Medicines Compendium. Dated October 2021.
- Manufacturer's PIL, Neoclarityn® Oral Solution; Organon Pharma (UK) Limited, The electronic Medicines Compendium. Dated October 2021.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 18 Dec 2027
19 Jun 2023 | Latest version

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