Can I take Aspirin and Atorvastatin together?
Drug interaction guide
Originally published 24 Jan 2026
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There is no harmful interaction between aspirin and atorvastatin. In fact, these two medicines are very commonly prescribed together by doctors to help prevent heart attacks and strokes.
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Why this happens
Aspirin works by making the blood less 'sticky' (antiplatelet), while atorvastatin works by lowering cholesterol in the liver. Because they work in completely different ways and are processed by different pathways in the body, they do not interfere with each other.
What you should do
You can safely take these medicines together as prescribed by your doctor. It is usually recommended to take atorvastatin in the evening, while aspirin is often taken after a meal to protect your stomach.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking aspirin with Nustendi (which contains bempedoic acid and ezetimibe) may slightly increase the levels of bempedoic acid in your blood. Additionally, if you are taking high doses of aspirin (over 325mg daily), there is a theoretical risk that it could interfere with how bempedoic acid works to lower your cholesterol.

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Can I take Fluoxetine and Tramadol together?
Taking these two medicines together can lead to a rare but very serious condition called 'serotonin syndrome'. This happens when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle stiffness, or diarrhoea. In extreme cases, it can cause seizures. Additionally, fluoxetine can make tramadol less effective at relieving your pain.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

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