Can I take Fluoxetine and Tramadol together?

Why this happens

Both fluoxetine and tramadol increase the levels of serotonin in the brain. When used together, these effects add up and can reach dangerous levels. Furthermore, fluoxetine blocks a specific enzyme in the liver (CYP2D6) that is responsible for converting tramadol into its active, pain-killing form. This means the tramadol may not work as well for your pain, while the risk of side effects actually increases.

What you should do

You should speak to your doctor before taking these two medicines together. They may prefer to prescribe an alternative painkiller that does not interact with your antidepressant. If your doctor decides you must take both, they will monitor you closely. Seek urgent medical help if you experience extreme confusion, shivering, very high fever, or muscle twitching.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.