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Can I take Aspirin and Ramipril together?

Drug interaction guide

Taking aspirin and ramipril together can sometimes make the ramipril less effective at lowering your blood pressure. There is also a small risk that the combination could affect how well your kidneys work, especially if you are older, dehydrated, or already have kidney problems.

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Why this happens

Ramipril works by relaxing blood vessels through a chemical process in the body. Aspirin (especially at higher doses) can block the production of substances called prostaglandins, which help ramipril work and also help protect the kidneys. When these are blocked, blood pressure may rise slightly and the kidneys may have to work harder.

What you should do

If you are taking low-dose aspirin (75mg to 150mg) for heart protection, it is usually fine to take with ramipril, but your doctor should still monitor your blood pressure and kidney function. Avoid taking high-dose aspirin (for pain or fever) regularly without speaking to your doctor. Ensure you stay well-hydrated and report any signs of swelling in your ankles or changes in how often you urinate.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
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