Can I take Chaga and Reishi together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking chaga and reishi together may significantly increase the risk of bruising or bleeding. Both mushrooms have 'blood-thinning' properties, meaning they can slow down how quickly your blood clots. Combining them can have an additive effect, making it harder for your body to stop bleeding if you are injured. Additionally, both may lower blood sugar levels, which could lead to symptoms of low blood sugar (hypoglycaemia) such as dizziness or shakiness.
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Why this happens
Both chaga and reishi contain compounds that interfere with platelet aggregation (the way blood cells stick together to form clots). Chaga is also high in oxalates which can affect metabolism. Furthermore, both fungi possess hypoglycaemic properties, meaning they can both lower blood glucose through similar pathways in the body.
What you should do
Back to contentsUse caution when combining these supplements. If you are scheduled for surgery, stop taking both at least two weeks beforehand. You should consult your doctor before taking this combination if you are already taking prescribed blood thinners (like warfarin or aspirin), blood pressure medication, or diabetes medication. Monitor yourself for signs of unusual bruising, nosebleeds, or light-headedness.
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Important precautions
Back to contentsKidney disease or history of kidney stones
Chaga is extremely high in oxalates, which can cause permanent kidney damage or acute kidney failure, especially in those with existing renal issues.
Diabetes
These supplements can lower blood sugar levels; when combined with insulin or other diabetes medications, they may cause dangerously low blood sugar (hypoglycaemia).
Autoimmune diseases (e.g., Lupus, MS, Rheumatoid Arthritis)
Chaga can stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications.
Bleeding disorders or upcoming surgery
Both mushrooms can significantly thin the blood and increase the risk of bruising or dangerous bleeding; they must be stopped at least 2 weeks before any planned surgery.
Low blood pressure (hypotension)
Reishi can lower blood pressure and may cause it to drop too low if you already have low blood pressure or are taking medication to treat it.
Food and drink warnings
Back to contentsAlcohol
Chaga contains high levels of oxalates. Combining it with alcohol may increase the risk of kidney stones or kidney stress, as both substances can affect renal function. Use with caution.
Reishi may have a mild sedative effect or affect how your liver processes substances. Combining it with alcohol could potentially increase drowsiness or put extra strain on the liver. It is best to limit alcohol intake while taking this supplement.
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Using other medicines?
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Cod liver oil and Doxadura together?
Taking cod liver oil and doxazosin (Doxadura) together may cause your blood pressure to drop lower than intended. This can make you feel dizzy, lightheaded, or faint, especially when standing up quickly. Additionally, cod liver oil has a mild blood-thinning effect, which could slightly increase the risk of bruising or bleeding when taken with other medications.

Treatment and medication
Can I take Lions mane and White button together?
There are no known harmful interactions between Lion's Mane (Hericium erinaceus) and White Button mushrooms (Agaricus bisporus). Both are edible fungi that are commonly consumed as food or supplements.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

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