Can I take Ciprofloxacin and Doxycycline together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking ciprofloxacin and doxycycline together may slightly increase the risk of side effects, such as skin sensitivity to sunlight or digestive upset. There is also a theoretical possibility that they could interfere with each other's ability to kill bacteria, though they are sometimes prescribed together for specific complex infections.
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Why this happens
Both are antibiotics but they work in different ways. Doxycycline stops bacteria from growing (bacteriostatic), while ciprofloxacin actively kills them (bactericidal). In some cases, stopping the growth can make the 'killing' antibiotic less effective, though this is rarely a problem in clinical practice. Both drugs also share a side effect of making your skin more sensitive to UV light.
What you should do
You can take these together if your doctor has specifically prescribed both. Ensure you wear high-factor sunscreen and protective clothing, as both drugs increase your risk of severe sunburn. If you experience severe diarrhoea or stomach pain, contact your doctor immediately. Take them at least 2 hours apart from any antacids, dairy, or iron supplements, as these can stop both medicines from being absorbed properly.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

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