Can I take Co-amoxalav and Ramipril together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking co-amoxiclav and ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). It may also increase the risk of high potassium levels in the blood or affect your kidney function, especially if you are already unwell with an infection.
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Why this happens
Both drugs can affect how the kidneys work and how the body handles potassium. Additionally, certain types of antibiotics (like co-amoxiclav) may rarely increase the risk of swelling reactions when taken with ACE inhibitors like ramipril.
What you should do
It is generally safe to take these together, but you should be aware of the signs of an allergic reaction. Seek immediate medical help if you experience swelling of the face, lips, or tongue, or have difficulty breathing. Your doctor may want to check your kidney function or potassium levels with a blood test if you are taking these for a long period or if you are feeling very unwell.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Antibiotics and Paracetamol together?
For the vast majority of antibiotics, there is no interaction with paracetamol. However, a specific interaction exists with the antibiotic flucloxacillin, which can lead to a rare but serious blood chemistry imbalance called high anion gap metabolic acidosis (HAGMA). This is more likely in patients with risk factors such as kidney problems, sepsis, or malnutrition.

Treatment and medication
Can I take Atenolol and Co-amoxalav together?
There is no known direct interaction between atenolol and co-amoxiclav. It is generally safe to take these two medications together.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

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