Can I take Antibiotics and Paracetamol together?

Why this happens

Flucloxacillin can interfere with how the body processes a substance called glutathione. When paracetamol is also taken, it can lead to a buildup of an acid called 5-oxoproline in the blood.

What you should do

It is generally safe to take paracetamol with most antibiotics. However, if you are prescribed flucloxacillin, inform your doctor if you have kidney issues or are feeling generally very unwell. If you develop deep, rapid breathing, confusion, or extreme tiredness while taking both, seek medical advice immediately.

Important precautions

Liver disease

You must not exceed the maximum dose, as paracetamol is highly toxic to the liver in overdose. If you have existing liver problems or drink alcohol heavily, you are at much higher risk of fatal liver damage.

Severe Allergy

If you have ever had a severe allergic reaction (such as hives, swelling, or breathing difficulties) to any antibiotic, you must inform your healthcare provider, as cross-reactivity between different types is common and can be life-threatening.

Alcohol consumption

You must strictly avoid all alcohol while taking these antibiotics and for 48-72 hours after finishing the course. Combining them causes a severe 'disulfiram-like' reaction, resulting in intense vomiting, racing heart, and chest pain.

Food and drink warnings

Alcohol

You must not drink alcohol while taking these antibiotics and for at least 48 to 72 hours after finishing the course. Doing so can cause a severe reaction including nausea, vomiting, flushing, and a racing heartbeat.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.