Can I take Felodipine and Grapefruit together?

Why this happens

Your body uses a specific enzyme (called CYP3A4) in the gut and liver to break down felodipine. Grapefruit contains natural compounds that block this enzyme. When the enzyme is blocked, your body cannot clear the medicine properly, leading to much higher levels of the drug than intended.

What you should do

You must completely avoid grapefruit and grapefruit juice while taking felodipine. Even a single glass of juice or half a grapefruit can cause this effect, and the impact can last for several days. If you have already consumed grapefruit, monitor your blood pressure and watch for dizziness or a racing heart. Speak to your doctor or pharmacist about safe fruit alternatives, such as oranges or lemons.

Important precautions

Grapefruit consumption

You must not eat grapefruit or drink grapefruit juice while taking felodipine. Grapefruit significantly increases the amount of felodipine in your blood, which can cause your blood pressure to drop dangerously low and increase the risk of side effects.

Food and drink warnings

Grapefruit and grapefruit juice

Grapefruit can significantly increase the amount of felodipine in your blood. This can lead to a dangerous drop in blood pressure and increase the risk of side effects like headaches, dizziness, and swelling. You should avoid eating grapefruit or drinking grapefruit juice while taking this medicine.

Alcohol

Drinking alcohol while taking felodipine can increase the blood-pressure-lowering effect of the medicine. This may make you feel dizzy, lightheaded, or faint, especially when standing up. It is best to keep your alcohol intake to a minimum.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.