Can I take Ibuprofen and Ibuprofen lysine together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking these two medications together is effectively taking a double dose of the same medicine. This significantly increases your risk of serious side effects, such as stomach ulcers, internal bleeding, and kidney problems.
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Why this happens
Ibuprofen and ibuprofen lysine are the same active drug. Ibuprofen lysine is simply a version of ibuprofen that is absorbed more quickly by the body. Taking both at once leads to an overdose of the medication.
What you should do
Do not take these two products together. Choose one or the other. If you have already taken both, watch for signs of stomach pain, black tarry stools, or nausea, and contact a healthcare professional if you feel unwell.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published
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