Skip to main content

Can I take Ibuprofen lysine and Paracetamol together?

Drug interaction guide

It is safe to take ibuprofen lysine and paracetamol together. These two medicines work in different ways to relieve pain and reduce fever. Taking them together can often provide better pain relief than taking either one alone.

Continue reading below

Why this happens

Paracetamol and ibuprofen belong to different classes of painkillers. Paracetamol works mainly in the central nervous system to block pain signals, while ibuprofen (an NSAID) reduces inflammation and pain at the site of the injury. Because they work through different pathways, they do not interfere with how the body absorbs or processes each other.

What you should do

You can take these medicines at the same time or stagger them. Always follow the dosage instructions on the packaging for each product. Ensure you do not take more than the maximum daily dose for either medicine. If you are using a 'combination' product that already contains both, do not take extra paracetamol or ibuprofen on top of it.

Continue reading below

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.