Can I take Ibuprofen lysine and Sertraline together?

Why this happens

Sertraline (an SSRI) and ibuprofen (an NSAID) both affect how your blood clots. Sertraline reduces the amount of serotonin in your blood platelets, which they need to stick together, while ibuprofen directly interferes with the clotting process and can irritate the lining of the stomach. Together, they make it much harder for your body to stop small bleeds.

What you should do

Speak to your doctor before taking these together. They may suggest a different painkiller, such as paracetamol, or prescribe a medicine to protect your stomach. Seek medical help immediately if you notice signs of bleeding, such as black or tarry stools, vomiting blood (which may look like coffee grounds), or unexplained bruising.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.