Can I take Lisinopril and Ibuprofen together?

Why this happens

Lisinopril works by relaxing blood vessels and helping the kidneys remove salt and water. Ibuprofen (an NSAID) blocks certain chemicals called prostaglandins. These chemicals are needed to keep the blood vessels in the kidneys open. When ibuprofen blocks them, it reduces blood flow to the kidneys and causes the body to retain salt and water, which opposes the blood-pressure-lowering effect of lisinopril.

What you should do

You should avoid taking ibuprofen regularly while on lisinopril. If you need pain relief, paracetamol is generally a safer choice. If you must take ibuprofen, use the lowest dose for the shortest time possible. Contact your doctor immediately if you notice decreased urination, swelling in your ankles or feet, or unusual tiredness. Your doctor may want to monitor your kidney function and blood pressure more closely.

Important precautions

Pregnancy

Lisinopril must not be taken during pregnancy as it can cause serious damage to the developing baby, particularly affecting their kidneys.

Asthma

Do not take ibuprofen if you have asthma that is worsened by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can trigger a severe or life-threatening asthma attack.

Kidney function

Taking lisinopril and ibuprofen together significantly increases the risk of sudden kidney failure. This risk is even higher if you are also taking a diuretic (water tablet).

Food and drink warnings

Potassium-rich foods and salt substitutes

Lisinopril can increase the levels of potassium in your blood. Avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of high-potassium foods like bananas, spinach, or pulses. High potassium levels can cause heart palpitations.

Alcohol

Drinking alcohol while taking lisinopril can increase the medicine's blood-pressure-lowering effect, which may make you feel dizzy or lightheaded. For ibuprofen, regular alcohol consumption can increase the risk of stomach irritation or stomach ulcers. It is best to keep alcohol intake within recommended limits.

Food (General)

While not an interaction that changes how the drug works, you should always take ibuprofen with food or a glass of milk. This helps to protect your stomach lining and reduce the risk of indigestion or stomach ache.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.