Can I take Metronidazole and Paracetamol together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
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There is no known interaction between metronidazole and paracetamol. It is generally safe to take these two medicines together.
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Why this happens
These medicines are processed by the body using different pathways in the liver and do not interfere with how the other works.
What you should do
You can take paracetamol for pain or fever while taking a course of metronidazole. Always follow the dosage instructions on the packet or as advised by your pharmacist. Remember to avoid drinking any alcohol while taking metronidazole and for at least 48 hours after finishing the course, as this can cause a severe reaction.
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Important precautions
Alcohol consumption
Do not drink any alcohol while taking metronidazole and for at least 48 hours after finishing the course. Doing so can cause a severe reaction including throbbing headaches, palpitations, feeling or being sick, and flushing.
Multiple medicine use
Do not take any other medicines containing paracetamol at the same time. Many cold and flu remedies and some painkillers contain paracetamol; taking more than one product can lead to a dangerous overdose.
Food and drink warnings
Alcohol
You must not drink any alcohol while taking metronidazole and for at least 48 hours after finishing the course. Combining the two can cause a 'disulfiram-like reaction', which includes severe nausea, vomiting, stomach cramps, hot flushes, a pounding heartbeat (palpitations), and headaches. This includes alcohol found in some mouthwashes or cough syrups.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published
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