Can I take Nikethamide and Venlafaxine dexcel together?

Why this happens

Both drugs affect the central nervous system. Nikethamide is a respiratory stimulant that increases brain activity, while venlafaxine (an antidepressant) can also increase electrical activity in the brain. When used together, their effects can add up, over-stimulating the brain and potentially triggering a seizure.

What you should do

You should avoid taking these two medications together. If you have a history of epilepsy or seizures, this combination is particularly risky. Speak to your doctor or pharmacist before using nikethamide if you are already taking venlafaxine. If you experience any unusual muscle twitching, confusion, or a seizure, seek emergency medical help immediately.

Important precautions

Serotonin Syndrome

Seek immediate medical help if you experience high fever, agitation, confusion, or muscle twitching, especially when starting or increasing the dose. This can be life-threatening if combined with certain other medicines.

Discontinuation Syndrome

Do not stop taking this medicine suddenly. Doing so can cause severe withdrawal symptoms like 'brain zaps' (electric shock sensations), intense dizziness, and anxiety. Your dose must be reduced gradually.

Epilepsy and Seizure Disorders

This medicine must not be used if you have a history of epilepsy or are prone to seizures, as it acts as a powerful respiratory stimulant that can trigger convulsions.

Food and drink warnings

Alcohol

You should avoid drinking alcohol while taking venlafaxine. Combining the two can increase drowsiness, dizziness, and impair your coordination and judgement.

Caffeine (Coffee, tea, energy drinks)

Nikethamide is a respiratory stimulant. Consuming high amounts of caffeine can increase the risk of side effects such as restlessness, tremors, rapid heartbeat (palpitations), and anxiety.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.