Can I take Omeprazole and Paracetamol together?

Why this happens

Omeprazole works by reducing stomach acid, while paracetamol is a painkiller processed mainly by the liver. They do not interfere with how each other is absorbed, broken down, or removed from the body.

What you should do

You can take these medicines at the same time. Always follow the dosage instructions on the packet or as advised by your doctor or pharmacist.

Important precautions

Liver disease or heavy alcohol consumption

You are at a significantly higher risk of fatal liver damage if you exceed the maximum dose or take multiple products containing paracetamol (such as cold and flu remedies).

Vitamin B12 deficiency or long-term use

Long-term use can mask the symptoms of stomach cancer and may lead to low magnesium levels or increased risk of bone fractures. Seek urgent medical advice if you experience unexplained weight loss or persistent vomiting.

Food and drink warnings

Alcohol

While alcohol does not directly interact with omeprazole, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms you are taking omeprazole to treat.

Using other medicines?

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.