Can I take Paracetamol and Naproxen together?

Why this happens

Paracetamol works mainly in the central nervous system to reduce pain signals and fever. Naproxen is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that works by blocking chemicals called prostaglandins that cause pain and inflammation at the site of an injury. Because they target pain through different pathways, their effects can be additive without interfering with how the body processes each drug.

What you should do

You can take these two medicines together if needed. Always follow the dosage instructions on the packaging or as directed by your pharmacist. Ensure you do not take any other products containing paracetamol (like some cold and flu remedies) or other NSAIDs (like ibuprofen or aspirin) at the same time. It is best to take naproxen with or after food to protect your stomach.

Important precautions

Asthma

Do not take this medicine if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack.

Stomach ulcers or bleeding

This medicine significantly increases the risk of stomach ulcers and internal bleeding. Avoid it if you have a history of stomach problems or are taking blood-thinning medication.

Liver health and dosing safety

Never exceed the maximum dose (usually 8 tablets in 24 hours) or take with other products containing paracetamol (such as cold and flu remedies), as this can cause fatal liver damage.

Food and drink warnings

Alcohol

While an occasional drink is generally safe, chronic heavy drinking or binge drinking increases the risk of serious liver damage when taking paracetamol. It is best to limit alcohol intake while using this medicine.

Food (General)

Naproxen should ideally be taken with or after food. This helps to protect the lining of your stomach and reduces the risk of indigestion or stomach ache.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.