Can I take Pregabalin and Paracetamol together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
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There are no known harmful interactions between pregabalin and paracetamol. It is generally safe to take these two medicines together.
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Why this happens
Pregabalin and paracetamol work in different ways and are processed by different organs in the body. Pregabalin is mainly cleared by the kidneys, while paracetamol is processed by the liver. They do not interfere with how the other is absorbed or removed from the body.
What you should do
You can take these medicines together as prescribed by your doctor or as directed on the packaging. Always stick to the recommended doses for both. If you feel unusually drowsy, speak to your pharmacist or doctor, as pregabalin itself can sometimes cause tiredness.
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Important precautions
History of substance misuse or addiction
Pregabalin carries a high risk of dependence and addiction. You must take it exactly as prescribed and be aware that it can be misused.
Pregnancy
Pregabalin should not be used during pregnancy as it may increase the risk of major birth defects. Effective contraception must be used during treatment.
Concurrent use of other medicines
Many over-the-counter remedies (such as cold and flu powders) contain paracetamol. Taking more than one product containing paracetamol can lead to a fatal overdose.
Food and drink warnings
Alcohol
Drinking alcohol while taking pregabalin can significantly increase feelings of sleepiness, dizziness, and confusion. It may also impair your coordination and increase the risk of breathing problems. It is best to avoid or strictly limit alcohol until you know how the medicine affects you.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published
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