Can I take Reishi and Shiitake together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking reishi and shiitake together may increase the risk of bruising or bleeding. Both mushrooms have natural properties that can slow down blood clotting. While this is generally safe for healthy individuals, it could be a concern if you are already taking blood-thinning medications or have an upcoming surgery.
In this article:
Continue reading below
Why this happens
Both reishi and shiitake contain compounds that have 'antiplatelet' effects. This means they make the tiny cells in your blood (platelets) less 'sticky', which slows down the formation of blood clots. Taking them together creates an additive effect, further thinning the blood.
What you should do
It is usually fine to take these together in standard food or supplement amounts if you are healthy. However, you should stop taking both at least two weeks before any scheduled surgery. If you take blood-thinning medications (like warfarin, aspirin, or clopidogrel), speak to your doctor before combining these supplements. Watch for unusual bruising, nosebleeds, or bleeding gums.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Warfarin and Amoxicillin together?
Taking amoxicillin while on warfarin can increase the risk of bleeding. You might notice that your blood takes longer to clot, or you may experience unusual bruising or nosebleeds.

Treatment and medication
Can I take Apixaban and Naproxen together?
Taking apixaban and naproxen together significantly increases your risk of serious bleeding. This includes internal bleeding, such as in the stomach or brain, which can be life-threatening. Signs to watch for include coughing up blood, vomit that looks like coffee grounds, black or tarry stools, or bruising that happens very easily.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.