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Can I take Reishi and Turkey tail together?

Drug interaction guide

Taking reishi and turkey tail together is generally considered safe, but both mushrooms have similar effects on the immune system and blood clotting. Combining them might increase the chance of thinning your blood or over-stimulating your immune system, though this is rarely a problem for healthy people.

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Why this happens

Both reishi (Ganoderma lucidum) and turkey tail (Trametes versicolor) contain bioactive compounds called polysaccharides (like beta-glucans) that modulate the immune system. They also both possess mild antiplatelet properties, meaning they can slow down how quickly your blood clots. Taking them together creates an additive effect, where the two supplements work in the same way to enhance these actions.

What you should do

It is usually fine to take these together, but you should speak to your doctor first if you are scheduled for surgery, take blood-thinning medication (like warfarin or aspirin), or have an autoimmune condition. Stop taking both at least two weeks before any planned surgical procedures to avoid excess bleeding.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
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