Can I take Royal sun and Turkey tail together?
Drug interaction guide
Originally published 24 Jan 2026
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Both Royal Sun (Agaricus blazei) and Turkey Tail (Trametes versicolor) are medicinal mushrooms that can stimulate the immune system. Taking them together may lead to an overactive immune response. Additionally, both may have mild blood-thinning effects and could lower blood sugar levels.
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Why this happens
These mushrooms contain beta-glucans which activate various immune cells (like natural killer cells and macrophages). Because they both work on similar pathways, their effects can add together (additive effect). They may also interfere with how blood clots and how the body processes glucose.
What you should do
If you have an autoimmune condition (like lupus or rheumatoid arthritis), are taking blood-thinning medication (like warfarin), or take medicine for diabetes, speak to your doctor before combining these supplements. If you are scheduled for surgery, stop taking both at least two weeks beforehand.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

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