Can I take Sertraline and Paracetamol together?

Why this happens

Sertraline (an SSRI antidepressant) and paracetamol (a painkiller) are processed by different pathways in the body and do not interfere with how the other works.

What you should do

You can take paracetamol while taking sertraline. Always follow the dosage instructions on the packet or as advised by your doctor. If you find you need to take paracetamol every day for more than a few days, speak to your GP.

Important precautions

Bleeding disorders or use of blood thinners (e.g. warfarin, aspirin)

Sertraline can increase your risk of serious bleeding, especially in the stomach. You must tell your doctor if you have a history of ulcers or take any medicines that thin the blood.

Low sodium levels (hyponatraemia)

Sertraline can cause a dangerous drop in blood sodium levels, particularly in elderly patients. Seek medical help if you experience severe confusion, muscle weakness, or seizures.

Liver disease or chronic alcohol use

Even a small amount over the recommended dose can cause fatal liver damage. You must strictly follow the dosage limits and avoid other products containing paracetamol (such as cold and flu remedies).

Food and drink warnings

Alcohol

It is best to avoid drinking alcohol while taking sertraline. Alcohol can increase the sedative effects of the medicine, making you feel more sleepy, dizzy, or uncoordinated. It can also worsen the symptoms of depression or anxiety that you are being treated for.

Grapefruit juice

Grapefruit juice can increase the levels of sertraline in your blood, which may increase the risk of side effects. While the effect is generally considered mild for sertraline compared to other medicines, it is often recommended to avoid drinking large amounts of grapefruit juice.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.