Can I take St john's wort and Fluoxetine together?

Why this happens

Both fluoxetine and St John's Wort work by increasing the levels of serotonin in the brain. When used together, they can raise these levels too high (a 'pharmacodynamic' interaction). Additionally, St John's Wort can change how the liver breaks down certain medicines, which can make the levels of fluoxetine in your blood unpredictable.

What you should do

Do NOT take St John's Wort if you are already taking fluoxetine (Prozac). If you are currently taking both, you should contact your GP or pharmacist immediately for advice before stopping either, as stopping antidepressants suddenly can also cause side effects. If you experience severe symptoms like confusion, high fever, or tremors, seek emergency medical help.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.