Can I take Shiitake and Turkey tail together?
Drug interaction guide
Originally published 24 Jan 2026
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There are no known harmful interactions between shiitake and turkey tail mushrooms. Both are medicinal fungi that are often taken together to support the immune system.
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Why this happens
Both mushrooms contain bioactive compounds called beta-glucans. These work in a similar way to support immune function without interfering with how the body processes the other.
What you should do
It is generally safe to take these together. However, as with any supplement, you should start with a small dose to ensure you do not have an individual sensitivity or digestive upset. Always inform your doctor about any supplements you are taking, especially if you are scheduled for surgery or have an autoimmune condition.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

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