Can I take Shiitake and Turkey tail together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There are no known harmful interactions between shiitake and turkey tail mushrooms. Both are medicinal fungi that are often taken together to support the immune system.
In this article:
Video picks for Drug interactions
Why this happens
Both mushrooms contain bioactive compounds called beta-glucans. These work in a similar way to support immune function without interfering with how the body processes the other.
What you should do
Back to contentsIt is generally safe to take these together. However, as with any supplement, you should start with a small dose to ensure you do not have an individual sensitivity or digestive upset. Always inform your doctor about any supplements you are taking, especially if you are scheduled for surgery or have an autoimmune condition.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Lions mane and Reisha together?
Both Lion's Mane and Reishi mushrooms have natural blood-thinning properties. Taking them together might increase the risk of bruising or bleeding, especially if you are already taking blood-thinning medication or have an upcoming surgery. Additionally, both may lower blood sugar levels, which could lead to feeling dizzy or shaky if levels drop too low.

Treatment and medication
Can I take Felodipine and Grapefruit together?
Drinking grapefruit juice or eating grapefruit while taking felodipine can significantly increase the amount of the medicine in your bloodstream. This can lead to a sudden drop in blood pressure, a faster heart rate, and increased side effects like flushing, headaches, or swollen ankles.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.