Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Heart Attack (Myocardial Infarction) article more useful, or one of our other health articles.
Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.
A careful and detailed clinical assessment is essential in order to assess the likely cause and severity of symptoms, arrange appropriate investigations and referral, avoid unnecessary investigations and to assess individual risk of cardiovascular disease or cardiomyopathy.
The most common and most important cardiac symptoms and history are:
- Chest pain, tightness or discomfort.
- Shortness of breath.
- Syncope ('blackouts', 'faints', 'collapse') or dizziness.
- Related cardiovascular history, including transient ischaemic attacks, stroke, peripheral arterial disease and peripheral oedema.
See also separate Chest Pain and Cardiac-type Chest Pain Presenting in Primary Care articles.
- Chest pain is very important as a symptom of heart disease but is sometimes difficult to evaluate.
- Location: usually in the front of the chest (retrosternal) but can also be in the upper abdomen, neck, jaw, left arm or left shoulder.
- Radiation: may spread to the neck, jaw, back and left or right arm.
- Nature: chest pain due to cardiac ischaemia is typically tight and crushing in quality:
- Patients tend to describe the angina pains with the flat of their hand horizontally across the middle of their chest; they tend to describe oesophageal spasms with a clenched fist at the upper xiphisternum edge, moving in a vertical manner.
- Patients may refer to anginal pain as indigestion.
- Other features include duration, aggravating and relieving factors and associated symptoms - eg, nausea and/or vomiting, sweating, dizziness and palpitations.
See also separate Breathlessness article.
- Cardiac causes include severe pulmonary oedema, acute myocardial infarction, cardiac arrhythmia, pericarditis and pericardial effusion.
- Dyspnoea on exertion is the most common type of dyspnoea and may precede other evidence of heart failure.
- Orthopnoea: ask whether the patient has to sleep propped up at night and if so with how may pillows.
- Establish whether there is any paroxysmal nocturnal dyspnoea or breathlessness at rest. These may last from minutes to hours and be accompanied by wheezing, sweating, distress and cough with frothy or bloodstained sputum. This is commonly termed 'cardiac asthma', although uraemia may cause similar symptoms.
- Cheyne-Stokes or periodic breathing: this often occurs during sleep, with a long cycle time; it may be found in chronic pulmonary oedema or poor cardiac output.
See also separate Palpitations article.
- Palpitations do not necessarily indicate any underlying cardiac pathology but may be presentation of a cardiac arrhythmia.
- Description may be bumping, throbbing, or thumping.
- Rhythm: ask the patient to tap out the rate and regularity; a missed beat or an extra large bump suggests extrasystoles.
- Duration: sudden short episodes suggest paroxysmal tachycardia; longer duration with irregularities suggests atrial dysrhythmia.
- Associated symptoms: pain, dyspnoea, feeling faint or syncope.
Other history to explore
- Drugs/medication: prescribed, over-the-counter, or illegal drug abuse.
- Associated cough:
- Duration, paroxysms or constant, dry or productive?
- Associations: is it related to chest pains; any fever or shivering fits?
- Sputum: colour, quantity and any haemoptysis?
- Limb ischaemia, intermittent claudication.
- Gastrointestinal symptoms: chronic heart failure may cause abdominal discomfort due to liver enlargement and abdominal distension.
- May present with failure to thrive in children or weight loss in adults (although fluid retention caused by heart failure will cause an increase in body weight).
- Urinary symptoms: oliguria can be an important symptom of heart failure.
- Cerebral symptoms:
- Syncope of cardiac origin may closely resemble benign vasovagal attacks and can be caused by aortic stenosis or regurgitation (or even pulmonary stenosis), or excessively fast or slow ventricular rate (heart block, atrial dysrhythmia, paroxysmal tachycardia).
- Dizziness, headache, and mental changes are not uncommon symptoms of severe hypertension, arterial degeneration and cardiac failure.
Past medical history
- Enquire about any raised blood pressure, heart problems, fainting fits, dizziness or collapses.
- Note whether there have been any heart attacks, any history of angina and any cardiac procedures or operations (type and date of intervention and outcome).
- Previous levels of lipids if ever checked or known.
- Ask whether there is any history of rheumatic fever or heart problems as a child.
- General: note any other operations or illnesses, especially history of myocardial infarction, hyperlipidaemia, hypertension, stroke, diabetes.
Ask about hypertension, coronary heart disease, stroke, diabetes, hyperlipidaemia, congenital heart disease and any early deaths (before the age of 60) in the family.
- Include ensuring appropriate primary prevention of cardiovascular disease (including calculation of cardiovascular risk) and secondary prevention of cardiovascular disease.
- Obesity: calculate body mass index (BMI); acute weight increase may indicate fluid retention and heart failure.
- Diet: healthy or unhealthy.
- Physical activity or inactivity, including exercise tolerance: ask whether there is anything that they cannot do because of any of the symptoms. It is best to try to quantify this - for example, inability to walk 50 yards rather than inability to walk. Note what changes they have had to make. For example, ask whether the patient stopped walking up the stairs or stopped work because of angina and/or breathlessness.
- Occupation: establish whether this is sedentary or active and, if the latter, how active.
- Stress levels - occupational and others.
- Build (obesity or wasting); shortness of breath; difficulty in talking; note whether they look ill.
- Look for pallor, jaundice, sweatiness and clamminess, and for xanthelasma around the eyes.
- Look for any evidence of syndromes or non-cardiovascular conditions associated with cardiovascular abnormalities - eg, Down's syndrome, Marfan's syndrome, Turner syndrome, ankylosing spondylitis.
- This is seen below the fingernails and toenails but also in the lips, cheeks, ears and nose.
- It may increase in the cold and on exertion.
- Cyanosis may be a very late sign in an anaemic patient, due to their low haemoglobin (because cyanosis depends on a finite amount of deoxygenated haemoglobin not the ratio of deoxygenated haemoglobin).
- In patients with dark skin, cyanosis is best seen on the inner lining of the eyelids or the inner surface of the lips.
- Malar flush - redness around the cheeks (mitral stenosis).
- Xanthomata - yellowish deposits of lipid around the eyes, palms, or tendons (hyperlipidaemia).
- Corneal arcus - a ring around the cornea (normal ageing or hyperlipidaemia).
- Proptosis - forward projection or displacement of the eyeball (Graves' disease).
- Finger clubbing.
- Splinter haemorrhages (infective endocarditis).
- Janeway lesions - macules on the back of the hands (infective endocarditis).
- Osler's nodes - tender nodules in the fingertips (infective endocarditis).
- Sweaty palms, tremor (thyrotoxicosis).
- Lax joints (Marfan's syndrome).
- Visible capillary pulsations in the nail bed (Quincke's sign - often seen in aortic regurgitation but can occur in normal individuals if the skin is warm, and in hyperthyroidism; can also be seen by pressing a glass slide on an everted lip).
See also separate Pulse Examination article.
- Rate: average 72/minute in adults, faster in children and may slow in old age. Also slower in athletes. Compare with apex rate.
- Respiratory variations are common in healthy individuals (if there is noticeable quickening in inspiration and slowing in expiration, this is termed sinus arrhythmia).
- The most common irregularities are atrial arrhythmias and extrasystoles (which may disappear on exertion).
- Thready, strong, bounding, collapsing ('water hammer' and its 2-stroke, dicrotic/hyperdicrotic variant) or slow-rising (plateau) or anacrotic (variant of slow-rising, with an extra wave on the upstroke).
- A pulse that weakens in inspiration is called 'pulsus paradoxus' (as opposed to the normal increase in volume) and is found in constrictive pericarditis, pericardial effusion, restrictive cardiomyopathy and severe asthma.
- 'Pulsus alternans' (an alternate variation in size of pulse wave) is an important sign of left ventricular failure but may be normal in the presence of a fast ventricular rate.
- 'Pulsus bigeminus': groups of two heartbeats close together followed by a longer pause. The second pulse is weaker than the first. Pulsus bigeminus is caused by premature ventricular contractions after every other beat. It can be a sign of heart disease, particularly hypertrophic obstructive cardiomyopathy, or may be an innocent and temporary phenomenon.
- Inequality of pulses:
- Radials: congenital abnormality, aortic arch aneurysm, a few cases of coarctation of the aorta, supravalvular aortic stenosis (rare), Takayasu's disease and occlusion of the subclavian artery by external pressure.
- Lower limb arteries: atherosclerosis of the larger arteries is the most common cause. Arterial embolism is an important cause in both the upper and lower limbs.
- Dissecting aortic aneurysm may cause progressive occlusion, and even reappearance if re-entry occurs.
- Arteritis and other inflammatory diseases occasionally cause occlusion.
- Peripheral pulses:
- Femoral pulses (radial femoral delay in coarctation) and foot and ankle pulses.
- Listen over the renal and femoral artery for murmurs.
Check blood pressure
- This should be measured in the brachial artery, using a cuff around the upper arm.
- A large cuff must be used in obese people, because a small cuff will result in the blood pressure being overestimated.
- Systolic pressure is at the level when first heard (Korotkoff I) and the diastolic pressure is when silence begins (Korotkoff V).
- In patients with chest pain, or if ever the radial pulses appear asymmetrical, the pressure should be measured in both arms because a difference between the two may indicate aortic dissection.
- Check the level of the jugular venous pressure.
- Chest examination:
- Look to see if the chest wall is deformed (eg, funnel chest) and moves equally (inequality of expansion is usually due to respiratory disease).
- Note the respiratory rate; it is related to the pulse rate in the ratio of about 1:4 and remains constant in the same individual.
- Ask the patient to breathe out and, using both hands resting lightly on the side walls of the chest with thumbs meeting in the middle, ask them to breathe in to assess the expansion of the chest on full inspiration by noting how far the examiner's thumbs move apart.
- Observe and palpate the trachea to detect any deviation to the left or right (noting any thyroid swelling); otherwise, a false impression may be given of cardiac enlargement if the apex beat is displaced towards the axilla.
- Palpate and percuss to find any areas of dullness (fluid or lung collapse); palpate with the flat hand over the 5th intercostal space to feel the maximum impulse (apex of the heart) and note its position; the apex is better defined by the light use of two fingers (noting the rib space and its position relative to an imaginary line dropped from the middle of the clavicle).
- Feel over the anterior chest wall for any thrills associated with cardiac murmurs.
- Auscultation of the heart - see separate Heart Auscultation and Heart Murmurs in Children articles.
Examination of other areas
- Abdomen - see also separate Abdominal Examination article:
- Palpate the abdomen for hepatomegaly and splenomegaly (congestive cardiac failure), or spleen alone (infective endocarditis).
- Feel for enlargement of the aorta (aneurysm); feel with the hands flat either side of the aorta - feel for pulsation and tenderness.
- Peripheral oedema:
- Assess ankle swelling by pressing the thumb firmly (not hard) above the medial malleolus and see if it leaves an impression.
- In a bed-bound patient the swelling is likely to be in the sacral area, genitalia and back of the thighs, rather than the ankles.
- Oedema may also cause pleural effusion, pericardial effusion or ascites.
- Look for the silver wiring effect in hypertension, swollen disc in malignant hypertension, microaneurysms and fluffy deposits.
- Also, look for Roth's spots in infective endocarditis.
- These may include:
- Blood tests (for fasting glucose and/or glycosylated haemoglobin, renal function, LFTs, TFTs, lipid profile, cardiac enzymes, ESR or CRP).
- 12-lead ECG and ambulatory ECG monitoring, exercise ECG testing.
- Ambulatory blood pressure monitoring.
- Cardiac catheterisation.
- NB: computer-assisted auscultation uses a digital stethoscope combined with acoustic neural networking to provide a visual display of heart sounds and murmurs and analyses the recordings to distinguish between innocent and pathological murmurs. This may be used more in the future.
Further reading and references
Bank I, Vliegen HW, Bruschke AV; The 200th anniversary of the stethoscope: Can this low-tech device survive in the high-tech 21st century? Eur Heart J. 2016 Feb 22. pii: ehw034.
Zuhlke L, Myer L, Mayosi BM; The promise of computer-assisted auscultation in screening for structural heart disease and clinical teaching. Cardiovasc J Afr. 2012 Aug23(7):405-8. doi: 10.5830/CVJA-2012-007. Epub 2012 Feb 23.