The International Society for the Study of Vulvovaginal Disease (ISSVD) defines vulvodynia as a chronic discomfort involving the vulva in the absence of relevant visible findings or a specific, clinically identifiable, neurological disorder.[1, 2]It is usually described by women experiencing it as a burning or soreness rather than a pain. It is a diagnosis of exclusion and in the case of a cause being found, the diagnosis would not be vulvodynia.
ISSVD classifies vulvodynia by location (generalised vs localised) and then subclassifies these two groups into whether symptoms are provoked or not as follows:
- Generalised vulvodynia - affecting the whole vulval area:
- Provoked - for example, by touch, sexual intercourse or tampon insertion.
- Unprovoked - present even without touch.
- Mixed (provoked and unprovoked).
- Localised vulvodynia - affecting a specific area of the vulva. This includes clitorodynia (where the clitoris is affected), vestibulodynia (where the vaginal vestibule is affected, previously known as vulval vestibulitis), hemivulvodynia, etc:
There may be overlap between these categories. Vulval pain caused by recognised conditions is not categorised as vulvodynia but rather as "vulval pain related to a specific disorder".
Aetiology is not understood and is likely to be multifactorial. There are a number of theories which include:
- A trigger causing inflammation or injury, causing stimulation of pain receptors, and receptor/nerve damage. Triggers possibly involved could be infections, skin conditions, allergies, trauma or hormonal factors.
- General urogenital hypersensitivity.
- Disordered central pain processing.
- Somatoform pain disorder.
Associations with other chronic pain conditions are common, with one study finding 45% of women with vulvodynia also having one of the following:
- Irritable bowel syndrome
- Chronic fatigue syndrome
- Interstitial cystitis
A history of recurrent vulvovaginal candidiasis is commonly associated.
Women with a past history of anxiety and/or depression are more likely to get vulvodynia.
- Vulvodynia affects women of all ages and ethnicity.
- Lifetime prevalence has been estimated at 8% and is constant across all decades up to the age of 70.
- Provoked vestibulodynia is the most common presentation.
The diagnosis of vulvodynia requires a careful history and confirmatory physical examination. Failure to achieve a satisfactory diagnosis can result in increasing frustration and worsening psychological problems along with phobia about sexually transmitted infections and cancer.
The vulval discomfort is often described as burning, stinging, irritation or rawness.
A thorough history should be taken to include:
- Duration of pain.
- Location of pain and radiation.
- Severity of pain.
- Type of pain, relieving factors. Whether pain is provoked and, if so. what by (touch, tampons, sexual intercourse, clothes, sitting, etc).
- Sexual history where appropriate - to include questions about vaginismus, lubrication, arousal, anorgasmia, relationship issues, whether pain is provoked by intercourse.
- Previous treatments.
- Medical, surgical and gynaecological history.
- Impact of pain on life.
- Presence of mood disorders.
- Little or nothing abnormal is apparent on inspection.
- The purpose of examination is to localise the pain and to exclude other diagnoses.
- A moist, cotton tip applicator can be used to touch the vestibulum lightly in order to "pain map". A mirror may be helpful so the woman can visualise the area being touched and ascertain which areas are affected.
- Inspect/palpate for signs which indicate other diagnoses:
- Skin changes (lichen sclerosis, neoplasia, rashes, inflammation).
- Atrophic change.
- Changes to normal anatomy.
- Signs of infection - discharge, inflammation.
- Abnormal muscle tone.
- Ischial spine tenderness (sign of pudendal neuralgia rather than vulvodynia).
- Bladder neck tenderness.
- A vaginal swab may be useful to rule out infection.
- A biopsy may be required if there are abnormalities on inspection, in which case vulvodynia has already been excluded as a diagnosis.
Alternative causes of vulvovaginal discomfort or dyspareunia include:
- Infection, including candidal vulvovaginitis, genital herpes, chlamydia, gonorrhoea, trichomoniasis, tinea.
- Lichen planus.
- Lichen sclerosus.
- Pudendal neuralgia.
- Vulval atrophy.
- Vulval intraepithelial neoplasia.
- Contact dermatitis.
- Vaginal septa or adhesions.
- Vulvodynia has many possible treatments; however, very few controlled trials have been performed to verify efficacy of these treatments.
- The British Society for the Study of Vulval Disease (BSSVD) guidelines recommend a multidisciplinary approach and advise that combining treatments can be helpful in dealing with different aspects of vulval pain. Specialities which may be involved include psychosexual medicine, physiotherapy, clinical psychology and pain management teams.
- Furthermore, these guidelines encourage patient education and reassurance as being vital to good management. Patient information leaflets and explanation that this is a recognised pain condition may be helpful. Women often fear pathology such as sexually transmitted infection or cancer; understanding the nature of the condition goes some way to alleviating distress.
- Avoidance of contact irritants should be advised. This includes wearing cotton underwear, not wearing underwear at night, avoiding perfumed products such as soaps and sanitary towels, etc.
- Avoidance of unnecessary topical preparations such as antifungals should be advised.
- Advise use of emollient soap substitutes.
Topical applications of local anaesthetics such as 5% lidocaine ointment or 2% lidocaine gel may be helpful, particularly in allowing intercourse. This should be applied 20 minutes before intercourse and washed off prior to penetration, or a condom used or it may cause penile numbness. These treatments should be used with caution due to the risk of contact irritation.
Conventional analgesics and narcotics are not helpful in vulvodynia. Instead, medications used in other neuropathic disorders have been borrowed, including:
- Tricyclic antidepressants (TCAs) - frequently used as first-line therapy. Side-effects are common and there is insufficient evidence of efficacy at this time. Other antidepressants such as paroxetine and venlafaxine have been used in patients who could not tolerate TCAs.
- Gabapentin is commonly tried but the evidence base for this and other anticonvulsants such as pregabalin remains poor.
- Pain in the vulva can cause spasm of the adductor muscles of the thigh and other muscles in that region and physiotherapy can be beneficial.
- Pelvic floor exercises allowing relaxation of vaginal muscles may be useful.
- Biofeedback training has also been used to improve strength and relaxation of the pelvic floor musculature.
- Transcutaneous electrical nerve stimulation (TENS) and vaginal trainers are also used.
- Devices to make sitting more comfortable may also be helpful.
- Cognitive behavioural therapies (CBT) and psychotherapy have been used successfully to improve reported vulval pain.
- Mindfulness-based CBT is thought to improve sexual function and satisfaction in women with vulvodynia.
- Additional support may be required - including reassurance of the partner.
- Sexual, individual or relationship counselling may also be appropriate. Advice about ensuring adequate arousal (and therefore lubrication) prior to intercourse, use of different sexual positions and good communication may be helpful.
Occasionally a modified vestibulectomy is a treatment option:
- The aim is to remove hypersensitive tissue and replace with the advancement of normal vaginal mucosa.
- It is only appropriate for provoked vestibulodynia and tends to be reserved for patients who have had limited success with other therapies.
- Those who respond to topical lidocaine have a better outcome.
- High success rates have been reported where patients are carefully selected.
Complementary and alternative medicine
Where conventional medicine proves unsatisfactory, patients frequently turn to alternative practitioners. Few data are available on which to base recommendations for or against such treatments.
A GP should be able to provide empathy and education. Give the patient the opportunity to discuss her problems. Encourage perseverance with treatment. Refer to a specialist where diagnosis is in doubt or for multidisciplinary treatment. A first-line approach should include education, reassurance and general advice, perhaps followed by referral for physiotherapy and/or psychosexual counselling where appropriate.
Vulvodynia can have a significant detrimental effect on quality of life.Affected women may experience frustration, chronic stress, depression and sexual and relationship problems. It may have an adverse effect on the psychosexual health and quality of life of her partner.
The natural history of this disorder is not clear. There is a high placebo effect in trials, suggesting high rates of spontaneous improvement in symptoms. Many treatment options have shown good success rates. However, improvement may take time and a combination of therapies.
Further reading and references
Haefner HK; Report of the International Society for the Study of Vulvovaginal Disease terminology and classification of vulvodynia. J Low Genit Tract Dis. 2007 Jan11(1):48-9.
Sadownik LA; Etiology, diagnosis, and clinical management of vulvodynia. Int J Womens Health. 2014 May 26:437-49. doi: 10.2147/IJWH.S37660. eCollection 2014.
Guidelines for the management of vulvodynia; British Society for the Study of Vulval Disease Guideline Group (March 2010)
Nguyen RH, Ecklund AM, Maclehose RF, et al; Co-morbid pain conditions and feelings of invalidation and isolation among women with vulvodynia. Psychol Health Med. 201217(5):589-98. doi: 10.1080/13548506.2011.647703. Epub 2012 Feb 13.
UK National Guideline on the Management of Vulval Conditions; British Association for Sexual Health and HIV (2014)
Khandker M, Brady SS, Vitonis AF, et al; The influence of depression and anxiety on risk of adult onset vulvodynia. J Womens Health (Larchmt). 2011 Oct20(10):1445-51. doi: 10.1089/jwh.2010.2661. Epub 2011 Aug 8.
Vulvodynia; ACOG Committee Opinion: Number 345, October 2006: Obstet Gynecol. 2006 Oct108(4):1049-52.
Andrews JC; Vulvodynia interventions--systematic review and evidence grading. Obstet Gynecol Surv. 2011 May66(5):299-315. doi: 10.1097/OGX.0b013e3182277fb7.
Leo RJ, Dewani S; A systematic review of the utility of antidepressant pharmacotherapy in the treatment of vulvodynia pain. J Sex Med. 2013 Oct10(10):2497-505. doi: 10.1111/j.1743-6109.2012.02915.x. Epub 2012 Sep 13.
Reed BD; Vulvodynia: diagnosis and management. Am Fam Physician. 2006 Apr 173(7):1231-8.
Leo RJ; A systematic review of the utility of anticonvulsant pharmacotherapy in the treatment of vulvodynia pain. J Sex Med. 2013 Aug10(8):2000-8. doi: 10.1111/jsm.12200. Epub 2013 May 16.
Masheb RM, Kerns RD, Lozano C, et al; A randomized clinical trial for women with vulvodynia: Cognitive-behavioral therapy vs. supportive psychotherapy. Pain. 2009 Jan141(1-2):31-40. doi: 10.1016/j.pain.2008.09.031. Epub 2008 Nov 20.
Basson R; The recurrent pain and sexual sequelae of provoked vestibulodynia: a perpetuating cycle. J Sex Med. 2012 Aug9(8):2077-92. doi: 10.1111/j.1743-6109.2012.02803.x. Epub 2012 Jun 6.
Swanson CL, Rueter JA, Olson JE, et al; Localized provoked vestibulodynia: outcomes after modified vestibulectomy. J Reprod Med. 2014 Mar-Apr59(3-4):121-6.
Arnold LD, Bachmann GA, Rosen R, et al; Vulvodynia: Characteristics and Associations With Comorbidities and Quality of Life. Obstet Gynecol. 2006 Mar107(3):617-624.
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