Can I take 50 and Magnesium glycinate together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Magnesium can interfere with how the body absorbs 5-HTP, potentially making the 5-HTP less effective. Additionally, both substances can have a calming effect on the nervous system, which may lead to increased drowsiness or a very relaxed state in some people.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Magnesium can bind to other substances in the digestive tract, which may reduce the amount of 5-HTP that enters the bloodstream. Furthermore, both 5-HTP (which turns into serotonin) and magnesium influence neurotransmitters that regulate relaxation, leading to a combined (additive) effect on the central nervous system.
What you should do
Back to contentsIt is generally best to space these two supplements apart by at least 2 hours to ensure you get the full benefit of the 5-HTP. If you feel unusually sleepy or dizzy, reduce your dose and speak with a healthcare professional. Always consult your doctor before starting new supplements, especially if you are taking prescribed antidepressants.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Aged garlic extract and Calcium together?
There is no known significant interaction between aged garlic extract and calcium supplements. They are generally considered safe to take together.

Treatment and medication
Can I take Vitamin c and Vitamin d3 together?
There is no known harmful interaction between Vitamin C (ascorbic acid) and Vitamin D3 (cholecalciferol). In fact, these two vitamins are often taken together to support overall health.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.