Can I take 50 and Xarelto together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking 5-HTP with Xarelto (rivaroxaban) may increase your risk of bleeding or bruising. While 5-HTP is primarily used for mood or sleep, it can affect how your blood platelets work, which may add to the blood-thinning effect of Xarelto.
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Why this happens
Xarelto is an anticoagulant that prevents blood clots. 5-HTP increases serotonin levels in the body. Serotonin plays a role in how platelets (the cells that help blood clot) stick together. Combining these two can potentially interfere with the body's ability to stop bleeding.
What you should do
Back to contentsUse caution if combining these two. You should speak with your doctor or pharmacist before starting 5-HTP while taking Xarelto. Watch closely for signs of unusual bleeding, such as bleeding gums, nosebleeds, dark or tarry stools, or large unexplained bruises. If you experience any severe bleeding, seek medical help immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published

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