Can I take Abilify and Lamictal together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking Abilify (aripiprazole) and Lamictal (lamotrigine) together can increase the risk of certain side effects. You may feel more drowsy, dizzy, or have difficulty concentrating. In some cases, it can affect your physical coordination or lead to a rare but serious skin rash.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both medicines affect the central nervous system. When used together, their sedative effects can add up (pharmacodynamic interaction). While they do not significantly change each other's levels in the blood, their combined impact on brain chemistry increases the likelihood of side effects.
What you should do
Back to contentsYou should use caution when starting this combination. Do not drive or operate machinery until you are certain the medicines do not make you too drowsy or dizzy. It is illegal to drive if your driving is impaired by these medicines. Contact your doctor immediately if you develop a skin rash, fever, or swollen glands. Always follow your doctor's specific dosing instructions.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take 7.5mg and Medikinet together?
Taking Zopiclone and Medikinet (methylphenidate) together can cause a 'tug-of-war' effect in your body. Medikinet is a stimulant designed to wake you up and help you focus, while Zopiclone is a sedative designed to make you sleepy. Taking them at the same time can make both medicines less effective. Additionally, while Medikinet is active, it may be harder for you to fall asleep, even after taking Zopiclone. In some cases, mixing stimulants and sedatives can lead to unpredictable effects on your coordination, heart rate, or mental state (such as feeling confused or agitated).

Treatment and medication
Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.