Can I take Acetaminophen and Acyclovir together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There is no known direct interaction between paracetamol (acetaminophen) and aciclovir (acyclovir). Both medicines are generally safe to take together.
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Why this happens
These two medicines are processed by the body in different ways. Paracetamol is mainly broken down by the liver, while aciclovir is primarily removed from the body through the kidneys. Because they use different pathways, they do not interfere with each other's effectiveness or safety.
What you should do
Back to contentsYou can take paracetamol and aciclovir at the same time if needed. Always follow the dosage instructions on the packet or as prescribed by your doctor. It is best to avoid or strictly limit alcohol when taking paracetamol, as combining them increases the risk of liver damage. Ensure you drink plenty of water while taking aciclovir to help your kidneys process the medicine.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.

Treatment and medication
Can I take 7.5mg and Medikinet together?
Taking Zopiclone and Medikinet (methylphenidate) together can cause a 'tug-of-war' effect in your body. Medikinet is a stimulant designed to wake you up and help you focus, while Zopiclone is a sedative designed to make you sleepy. Taking them at the same time can make both medicines less effective. Additionally, while Medikinet is active, it may be harder for you to fall asleep, even after taking Zopiclone. In some cases, mixing stimulants and sedatives can lead to unpredictable effects on your coordination, heart rate, or mental state (such as feeling confused or agitated).
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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