Can I take Amitriptyline and Modifinil together?

Why this happens

Modafinil can slow down the liver enzymes (specifically CYP2C19) that are responsible for breaking down amitriptyline. Because the body cannot clear the amitriptyline as quickly as usual, the drug builds up in your system. Additionally, both drugs can affect heart rate and brain activity, which may lead to additive effects.

You should consult your doctor before taking these two medicines together. Your doctor may need to adjust your dose of amitriptyline or monitor you more closely for side effects. Seek medical help immediately if you experience a very fast or irregular heartbeat, severe dizziness, or fainting.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.