Can I take Amoxicillin and Sertraline together?

It is generally considered safe to take amoxicillin and sertraline together.

Amoxicillin is an antibiotic cleared by the kidneys, while sertraline is an antidepressant processed by the liver. They do not interfere with each other's absorption, metabolism, or effects on the body.

How to take amoxicillin and sertraline safely

• Take both medications as prescribed by your doctor.

• Be aware that both medications can sometimes cause side effects such as diarrhoea or an upset stomach.

• If you experience severe diarrhoea while taking the antibiotic, contact your GP.

Important precautions

Depression and anxiety disorders

You may experience an increase in suicidal thoughts or the urge to self-harm when first starting sertraline or changing the dose. This is more common in young adults under 25. Contact your doctor or go to hospital immediately if you notice any changes in your mood or behaviour.

Penicillin allergy

Do not take amoxicillin if you have ever had an immediate allergic reaction (such as a rash, swelling, or breathing difficulties) to any penicillin or cephalosporin antibiotic, as this can cause a life-threatening reaction.

Serotonin syndrome risk

Do not take sertraline if you are taking, or have taken in the last 14 days, an MAOI antidepressant (such as phenelzine or selegiline), as this can cause a dangerous and potentially fatal rise in serotonin levels.

Increased bleeding risk

Be aware that sertraline increases your risk of internal bleeding, especially if you also take aspirin, ibuprofen, or blood-thinning medications like warfarin.

Food and drink warnings

Alcohol

It is best to avoid drinking alcohol while taking sertraline. Alcohol can increase the sedative effects of the medicine, making you feel more sleepy, dizzy, or uncoordinated.

It is best to avoid or strictly limit alcohol while taking amoxicillin. While there is no direct chemical interaction, alcohol can dehydrate you and interfere with your sleep, which may slow down your recovery from infection. Additionally, both alcohol and amoxicillin can cause stomach upset or nausea, and combining them may make these side effects worse.

Grapefruit juice

Avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that can increase the level of sertraline in your blood, which may increase the risk of side effects.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.