Can I take Arcoxia and Levetiracetam together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There are no known direct interactions between Arcoxia (etoricoxib) and levetiracetam. However, both medications can occasionally cause side effects that affect your nervous system, such as dizziness or drowsiness. If you experience these, they may be slightly more noticeable when taking both drugs together. Additionally, Arcoxia can sometimes affect how well your kidneys work; since levetiracetam is removed from the body by the kidneys, any significant change in kidney function could theoretically affect levetiracetam levels.
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Why this happens
Arcoxia is a non-steroidal anti-inflammatory drug (NSAID) and levetiracetam is an anti-epileptic. They are processed by the body through different pathways (Arcoxia via the liver and levetiracetam via the kidneys), so they do not typically interfere with each other's metabolism. The main concern is a potential 'additive' effect on side effects like tiredness or the rare risk of Arcoxia affecting kidney clearance.
What you should do
Back to contentsIt is generally safe to take these two medications together. You should monitor yourself for increased tiredness or dizziness, especially when starting the combination. Ensure you stay well-hydrated to support your kidney health while taking Arcoxia. If you have a history of kidney problems, you should inform your doctor before taking Arcoxia.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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