Can I take Ashwagandha and Solifenacin together?

Caution is advised when taking ashwagandha and solifenacin together. Using them together can increase the risk of side effects such as blurred vision and sleepiness.

Additionally, ashwagandha may slightly influence the liver enzymes (CYP3A4) that break down solifenacin, potentially leading to higher levels of the medicine in your body.

Why this happens

Both substances can affect the central nervous system. Ashwagandha is thought to have GABAergic (calming) effects, while solifenacin is an anticholinergic medication.

How to take ashwagandha and solifenacin safely

• Use caution if combining these two.

• Always start with a low dose of ashwagandha to see how your body reacts while taking solifenacin.

• Stop taking ashwagandha and consult your doctor or pharmacist if you experience excessive sleepiness, severe dry mouth, constipation, or blurred vision

Important precautions

Glaucoma

Do not take solifenacin if you have narrow-angle glaucoma, as it can increase the pressure in your eyes and cause a sudden medical emergency.

Hyperthyroidism (overactive thyroid)

Ashwagandha can increase thyroid hormone levels. You must avoid it if you have an overactive thyroid, as it may worsen your condition or interfere with thyroid medications.

Surgery

You must stop taking ashwagandha at least two weeks before any scheduled surgery.

It can slow down your central nervous system and may dangerously increase the effect of anaesthesia and other medications used during surgery.

Food and drink warnings

Alcohol

Ashwagandha may have sedative effects. Combining it with alcohol can increase drowsiness, sleepiness, and impaired coordination.

Grapefruit juice

Drinking grapefruit juice may increase the level of solifenacin in your blood, potentially increasing the risk of side effects like dry mouth, blurred vision, and constipation.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.