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Can I take Aspirin and Empagliflozin together?

Drug interaction guide

Taking aspirin and empagliflozin together may slightly increase the risk of dehydration or a rare but serious condition called ketoacidosis (where the blood becomes too acidic). Aspirin can also occasionally affect how well the kidneys work, which might change how empagliflozin behaves in the body.

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Why this happens

Empagliflozin works by removing sugar and salt through the urine, which has a mild diuretic (water-losing) effect. High doses of aspirin can also affect kidney function and acid-base balance in the blood. While low-dose aspirin (75mg-150mg) is generally safe, combining them can theoretically increase the strain on the kidneys or contribute to metabolic changes.

It is generally safe to take low-dose aspirin with empagliflozin if prescribed by your doctor. However, you should stay well-hydrated by drinking plenty of water. Seek medical help immediately if you experience nausea, vomiting, stomach pain, confusion, or unusual tiredness, as these can be signs of ketoacidosis. Always inform your doctor if you are taking high-dose aspirin for pain relief.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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